Combined Consumption of Beef‐Based Cooked Mince and Sucrose Stimulates Oxidative Stress, Cardiac Hypertrophy, and Colonic Outgrowth of Desulfovibrionaceae in Rats. Issue 2 (14th November 2018)

• Record Type: Journal Article
• Authors: Van Hecke, Thomas; De Vrieze, Jo; Boon, Nico; De Vos, Winnok H.; Vossen, Els; De Smet, Stefaan
• Is Part Of: Molecular nutrition & food research. Volume 63:Issue 2(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-11-14
• Subjects: chronic disease -- colonic microbiota -- digestion -- oxidation -- red meat; Food -- Biotechnology -- Periodicals; Food -- Microbiology -- Periodicals; Nutrition -- Periodicals; Food -- Toxicology -- Periodicals; Nutrition -- Periodicals; Food Microbiology -- Periodicals; Food Technology -- Periodicals; Molecular Biology -- Periodicals; 664.0705
• DOI: 10.1002/mnfr.201800962
• Languages: English
• ISSNs: 1613-4125

Abstract

Abstract : Scope: High red meat and sucrose consumption increases the epidemiological risk for chronic diseases. Mechanistic hypotheses include alterations in oxidative status, gut microbiome, fat deposition, and low‐grade inflammation. Methods and results: For 2 weeks, 40 rats consumed a diet high in white or red meat (chicken‐based or beef‐based cooked mince, respectively), and containing corn starch or sucrose in a 2 × 2 factorial design. Lard was mixed with lean chicken or beef to obtain comparable dietary fatty acid profiles. Beef (vs chicken)‐fed rats had higher lipid oxidation products (malondialdehyde, 4‐hydroxy‐2‐nonenal, and hexanal) in stomach content and blood, and lower blood glutathione. Sucrose (vs corn starch)‐fed rats showed increased blood lipid oxidation products and glutathione peroxidase activity, higher liver weight and malondialdehyde concentrations, and mesenterial and retroperitoneal fat accumulation. Beef–sucrose‐fed rats had increased cardiac weight, suggesting pathophysiological effects on the cardiovascular system. The colonic microbiome of beef–sucrose‐fed rats showed an outgrowth of the sulfate‐reducing family of the Desulfovibrionaceae, and lower abundance of the Lactobacillus genus, indicating intestinal dysbiosis. Blood C‐reactive protein, a marker for inflammation, was not different among groups. Conclusions: Consumption of a cooked beef‐based meat product with sucrose increased oxidative stress parameters and promoted cardiac hypertrophy and intestinal dysbiosis. Abstract : For two weeks, 40 rats consumed a diet of a cooked chicken‐ or beef‐based meat product, in combination with either corn starch or sucrose. Consumption of the beef‐based meat product with sucrose increases oxidative stress and promotes cardiac hypertrophy and intestinal dysbiosis, demonstrated by an outgrowth of the sulfate‐reducing family of the Desulfovibrionaceae, and lower abundances of the Lactobacillus genus.