Bioaccessibility of curcumin encapsulated in yeast cells and yeast cell wall particles. (30th March 2020)

• Record Type: Journal Article
• Authors: Young, Stephen; Rai, Rewa; Nitin, Nitin
• Is Part Of: Food chemistry. Volume 309(2020)
• Publication Date: 2020-03-30
• Subjects: Bioactive compounds -- Cell-based carriers -- Simulated gastrointestinal digestion -- Confocal imaging -- Transmission electron microscopy; Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; 664
• DOI: 10.1016/j.foodchem.2019.125700
• Languages: English
• ISSNs: 0308-8146

Abstract

Highlights: Multimodal imaging shows limited structural change of cells-based carriers. Gastric treatment plays an essential role in bioaccessibility of phytochemicals. Bile salt is required for the release of phytochemicals during sequential digestion. Abstract: This study evaluates the role of intracellular composition and integrity of cell walls in modulating the release and bioaccessibility of phytochemicals during simulated gastrointestinal digestion of cell-based carriers. Native yeast and yeast cell wall particles (YCWPs) were used as model cell-based carriers with distinct intracellular composition and curcumin was a model encapsulated bioactive. The results highlight the essential role of gastric treatments and the presence of bile salts in the release and bioaccessibility of encapsulated compound from cell-based carriers. YCWPs with significantly reduced intracellular contents have a significantly faster intestinal release after gastric digestion. Multimodal imaging approaches confirm the release of encapsulated curcumin in intestinal compartment without any significant changes in the cellular structure including cell walls. Based on these results, the study proposes a model that illustrate the significance of gastric digestion in influencing the release of curcumin during gastrointestinal digestion.