Supplementing human milk with a donkey or bovine milk derived fortifier: Consequences on proteolysis, lipolysis and particle structure under in vitro dynamic digestion. (30th November 2022)

• Record Type: Journal Article
• Authors: Nebbia, Stefano; Deglaire, Amélie; Ménard, Olivia; Henry, Gwénaële; Barberis, Elettra; Manfredi, Marcello; Bertino, Enrico; Coscia, Alessandra; Dupont, Didier; Giribaldi, Marzia; Cavallarin, Laura
• Is Part Of: Food chemistry. Volume 395(2022)
• Publication Date: 2022-11-30
• Subjects: Human milk -- Donkey milk -- Cow's milk -- Fortification -- Preterm infants -- Simulated dynamic digestion; Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; 664
• DOI: 10.1016/j.foodchem.2022.133579
• Languages: English
• ISSNs: 0308-8146

Abstract

Highlights: Particle size in the gastric phase was higher with the donkey milk fortification. Donkey and bovine milk fortification reach a similar degree of proteolysis only at the end of the intestinal phase. Donkey and bovine milk fortification have a similar degree of lipolysis. A lower ω6/ω3 free PUFA ratio resulted with the donkey milk fortification. Abstract: Fortification of human milk (HM) is often necessary to meet the nutritional requirements of preterm infants. This study sought to establish whether HM supplemented with an experimental donkey milk-derived fortifier (DMF) or a commercial bovine milk-derived fortifier (BMF) affected digestion, using an in vitro dynamic system at the preterm stage. Particle size in gastric phase was higher in DMF than in BMF, due to protein aggregates surrounding lipid globules. Before digestion, BMF, with its extensively hydrolysed proteins, had a higher degree of proteolysis (30%) than DMF (11%), which contained intact proteins. After digestion, this difference was reduced concomitantly to a similar net degree of proteolysis (33%). DMF, with a higher proportion of ω3, resulted in a lower ω6/ω3 free PUFA ratio than BMF throughout digestion, although the final degree of lipolysis was similar (54%). In summary, DMF could represent a better source of proteins and lipids for the preterm infant.