Fabrication and characterization of soy β-conglycinin-dextran-polyphenol nanocomplexes: Improvement on the antioxidant activity and sustained-release property of curcumin. (30th November 2022)

• Record Type: Journal Article
• Authors: Wang, Zi-Jun; Xu, Jing-Jing; Ji, Fu-Yun; Luo, Shui-Zhong; Li, Xing-Jiang; Mu, Dong-Dong; Jiang, Shao-Tong; Zheng, Zhi
• Is Part Of: Food chemistry. Volume 395(2022)
• Publication Date: 2022-11-30
• Subjects: Curcumin (PubChem CID: 969516) -- Dextran (PubChem CID: 4125253); Soy β-conglycinin -- Self-assembly -- Dextran -- Curcumin -- Nanoparticles; Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; 664
• DOI: 10.1016/j.foodchem.2022.133562
• Languages: English
• ISSNs: 0308-8146

Abstract

Highlights: β-CG-DEX had pH-driven self-assemble ability. β-CG-DEX exhibited higher encapsulation-performance than β-CG. β-CG-DEX-Cur nanoparticles exhibited an eminent antioxidant activity. Glycation improved the digestive stability of nanocomplexes. Abstract: In this study, glycated soy β-conglycinin (β-CG) stabilized curcumin (Cur) composites were fabricated by a unique reversible self-assembly character of β-conglycinin-dextran conjugates (β-CG-DEX). Intrinsic fluorescence and far-UV CD spectra revealed that glycation did not affect the self-assembly property of β-CG in the pH-shifting treatment. The structure of β-CG-DEX could be unfolded at pH 12.0 and reassembled during acidification (from pH 12.0 to 7.0). Meanwhile, β-CG-DEX-3d, which was incubated at 60 °C for 3 days, exhibited a high loading capacity (123.4 mg/g) for curcumin, which far exceeds that (74.90 mg/g) of β-CG-Cur. Moreover, the reassembled β-CG-DEX-3d-Cur showed eminent antioxidant activity of approximately 1.5 times higher than that of free curcumin. During the simulated gastrointestinal condition, compared with β-CG-Cur, β-CG-DEX-3d-Cur nanoparticles showed a more stable and sustained release of curcumin. Thus, β-CG-DEX has immense potential to become a new delivery carrier for hydrophobic food components by means of a self-assembly strategy.