Alpha-tomatine and the two sides of the same coin: An anti-nutritional glycoalkaloid with potential in human health. (15th October 2022)

• Record Type: Journal Article
• Authors: Faria-Silva, Catarina; de Sousa, Miriam; Carvalheiro, Manuela Colla; Simões, Pedro; Simões, Sandra
• Is Part Of: Food chemistry. Volume 391(2022)
• Publication Date: 2022-10-15
• Subjects: CAN Acetonitrile -- AIF Apoptosis-inducing factor -- Akt Protein kinase B -- AP-1 Activator protein-1 -- DAD Diode array detection -- DNA Deoxyribonucleic acid -- ELS Evaporative light-scattering -- ELSD Evaporative light scattering detection -- ERK1/2 Extracellular signal-regulated kinase 1 and 2 -- ESI Electrospray ionization -- ESI-MS Electrospray ionization mass spectrometry -- EtOH Ethanol -- FAK Focal adhesion kinase -- GAME Glycoalkaloid metabolism -- GC Gas chromatography -- H2O Water -- HIV Human immunodeficiency virus -- HPLC High Performance Liquid Chromatography -- IC50 Half maximal inhibitory concentration -- IGF Insulin like growth factor -- LD50 Median lethal dose -- LDL Low-density lipoprotein -- MAE Microwave assisted extraction -- MeOH Methanol -- MMP Matrix metalloproteinase -- MS Mass spectrometry -- NF-κB Nuclear factor kappa B -- PAD Pulsed amperometry detection -- PI3K Phosphoinositide 3-kinase -- RCF Relative centrifugal force -- SGA Steroidal Glycoalkaloid -- SPE Solid-phase extraction -- SWE Subcritical water extraction -- TEAP triethylammonium phosphate -- UAE Ultrasound assisted extraction -- u-PA Urokinase-type plasminogen activator -- UV Ultraviolet; Alpha-tomatine -- Green tomatoes -- Steroidal glycoalkaloids -- Anticancer activity; Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; 664
• DOI: 10.1016/j.foodchem.2022.133261
• Languages: English
• ISSNs: 0308-8146

Abstract

Graphical abstract: Highlights: Safety reports of α-tomatine in food products are inconsistent with proposed biological activities. Green tomatoes constitute an important source of α-tomatine. Alpha-tomatine extraction from food waste is a valuable approach to obtain a bioactive agent. More studies of α-tomatine associated molecular and cellular mechanisms are needed. Alpha-tomatine application is not yet fully exploited in human health. Abstract: Discovery of new selective anticancer, anti-inflammatory, and anti-microbial agents is a crucial and necessary step to ensure a pipeline for innovative products to improve disease management. Several new bioactive agents derived from plants have been investigated and an example is the steroidal glycoalkaloid (SGA) class of natural products found in plants, investigated for their health-beneficial biological activities. Among them, α-tomatine is a SGA derived from the plant parts of unripe green tomatoes. In this review we aimed at searching for two different perspectives to study α-tomatine from green tomatoes, namely from its dual action point of view: as an anti-nutrient and as a health promoter. The aspects associated to its synthesis and degradation were considered. Finally, the current strategies for its extraction from natural sources and the methodologies commonly used for its identification and quantification were discussed.