Geographical Variation and Factors Associated with Non-Small Cell Lung Cancer in Manitoba. (21st June 2017)

• Record Type: Journal Article
• Authors: Dawe, David E.; Singh, Harminder; Wickramasinghe, Lahiru; Pitz, Marshall W.; Torabi, Mahmoud
• Other Names: Goto Akiteru Academic Editor.
• Is Part Of: Canadian respiratory journal. Volume 2017(2017)
• Publication Date: 2017-06-21
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiration -- Canada -- Periodicals; Respiration; Respiratory organs -- Diseases; Canada; Respiratory Tract Diseases -- Periodicals; Periodicals; Periodicals; 616.2
• DOI: 10.1155/2017/7915905
• Languages: English
• ISSNs: 1198-2241

Abstract

Abstract : Background . Screening decreases non-small cell lung cancer (NSCLC) deaths and is recommended by the Canadian Task Force on Preventive Health Care. We investigated risk factor prevalence and NSCLC incidence at a small region level to inform resource allocation for lung cancer screening. Methods . NSCLC diagnoses were obtained from the Canadian Cancer Registry, then geocoded to 283 small geographic areas (SGAs) in Manitoba. Sociodemographic characteristics of SGAs were obtained from the 2006 Canadian Census and Canadian Community Health Survey. Geographical variation was modelled using a Bayesian spatial Poisson model. Results . NSCLC incidence in SGAs ranged from 1 to 343 cases per 100, 000 population per year. The highest incidence rates were in the Southeastern, Southwestern, and Central regions of Manitoba, while most of Northern Manitoba had lower rates. Poisson regression suggested areas with higher proportions of Aboriginal people and higher average income, and immigrants had lower NSCLC incidence whereas areas with higher proportions of smokers had higher incidence. Conclusion . On an SGA level, smoking rates remain the most significant factor driving NSCLC incidence. Socioeconomic status and proportions of immigrants or Aboriginal peoples independently impact NSCLC rates. We have identified SGAs in Manitoba to target in policy and infrastructure planning for lung cancer screening.