Inflammatory factor expression in HaCaT cells and melanin synthesis in melanocytes: Effects of Ganoderma lucidum fermentation broth containing Chinese medicine. Issue 1 (31st December 2022)

• Record Type: Journal Article
• Authors: Meng, Xianyao; Yang, Yunli; Wu, Yuehang; Zhang, Ying; Zhang, Hongyan; Zhou, Weiqiang; Guo, Miaomiao; Li, Li
• Is Part Of: International journal of food properties. Volume 25:Issue 1(2022)
• Page Start: 1604
• Page End: 1621
• Publication Date: 2022-12-31
• Subjects: Ganoderma lucidum -- Panax ginseng -- Liquid fermentation -- Inflammatory factors -- Skin pigment deposition -- LC-MS/MS; Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; 664.0705
• DOI: 10.1080/10942912.2022.2096067
• Languages: English
• ISSNs: 1094-2912

Abstract

ABSTRACT: Ganoderma lucidum possesses anti-inflammatory, antioxidant, and immunomodulatory properties. We evaluated the anti-inflammatory and anti-melanogenesis effects of G. lucidum alone (S1), G. lucidum and Polygonatum odoratum (S2), and G. lucidum and P. ginseng (S3) using an ultraviolet B-irradiated HaCaT cell model and a prostaglandin 2 (PGE2)-treated B16-F10 melanocyte model. S3 inhibited PGE-2 and LL-37 secretion in HaCaT cells and melanin and tyrosinase expression in B16-F10 cells. Furthermore, LC/MS/MS results revealed that the levels of 70 components were higher in S3 than in S1 and S2. These results demonstrate that G. lucidum and P. ginseng co-culture fermentation broth possess in vitro anti-inflammatory and anti-melanogenesis effects; it can be used in the skin care industry.