Three new guaiane-type sesquiterpenoids and a monoterpenoid from Litsea lancilimba Merr. Issue 13 (1st July 2022)

• Record Type: Journal Article
• Authors: Muhammad, Ishaq; Xiao, Yong Zhen; Hassan, Syed Shams ul; Xiao, Xue; Yan, Shi-Kai; Guo, Yuan-Qiang; Ma, Xian-peng; Jin, Hui-Zi
• Is Part Of: Natural product research. Volume 36:Issue 13(2022)
• Page Start: 3271
• Page End: 3279
• Publication Date: 2022-07-01
• Subjects: Litsea lancilimba Merr -- Lauraceae -- sesquiterpenoids -- monoterpenoid -- anti-inflammatory activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2020.1853727
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Three undescribed guaiane-type sesquiterpenes (1–3 ), and a monoterpenoid (4 ) along with eleven known compounds (5 − 15 ) were isolated from the crude extract of Litsea lancilimba Merr. The structures of all the isolated compounds were extensively elucidated on the basis of comprehensive spectroscopic techniques (HRESIMS, 1 D NMR, and 2 D NMR). Their relative and absolute configurations were comprehensively established by NOESY spectroscopy, circular dichroism (ECD) and the calculated ECD analysis. All the isolates were tested for anti-inflammatory activity by measuring the amount of nitric oxide production. Amongst tested compounds, compounds 1 − 3 exhibited moderate inhibitory activities against the production of nitric oxide with IC50 value of 35.5, 32.1, 46.7 μ M in RAW264.7 cells stimulated by LPS, respectively. Graphical Abstract: UF0001