Three new guaiane-type sesquiterpenoids and a monoterpenoid from Litsea lancilimba Merr. Issue 13 (1st July 2022) - Muhammad, Ishaq
Abstract: Three undescribed guaiane-type sesquiterpenes (1–3 ), and a monoterpenoid (4 ) along with eleven known compounds (5 − 15 ) were isolated from the crude extract of Litsea lancilimba Merr. The structures of all the isolated compounds were extensively elucidated on the basis of comprehensive spectroscopic techniques (HRESIMS, 1 D NMR, and 2 D NMR). Their relative and absolute configurations were comprehensively established by NOESY spectroscopy, circular dichroism (ECD) and the calculated ECD analysis. All the isolates were tested for anti-inflammatory activity by measuring the amount of nitric oxide production. Amongst tested compounds, compounds 1 − 3 exhibited moderate inhibitory activities against the production of nitric oxide with IC50 value of 35.5, 32.1, 46.7 μ M in RAW264.7 cells stimulated by LPS, respectively. Graphical Abstract: UF0001