Clostridium butyricum Inhibits Fat Deposition via Increasing the Frequency of Adipose Tissue‐Resident Regulatory T Cells. Issue 12 (28th April 2022)

• Record Type: Journal Article
• Authors: Li, Haifang; Jia, Yanxin; Weng, Dan; Ju, Zijing; Zhao, Yunfei; Liu, Shuang; Liu, Yan; Song, Mengze; Cui, Lulu; Sun, Shuhong; Lin, Hai
• Is Part Of: Molecular nutrition & food research. Volume 66:Issue 12(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-04-28
• Subjects: adipogenesis -- Clostridium butyricum -- obesity -- Treg cells -- Wnt10b; Food -- Biotechnology -- Periodicals; Food -- Microbiology -- Periodicals; Nutrition -- Periodicals; Food -- Toxicology -- Periodicals; Nutrition -- Periodicals; Food Microbiology -- Periodicals; Food Technology -- Periodicals; Molecular Biology -- Periodicals; 664.0705
• DOI: 10.1002/mnfr.202100884
• Languages: English
• ISSNs: 1613-4125

Abstract

Abstract : Scope: Clostridium butyricum (CB) exerts beneficial actions in several disorders. However, the impact and molecular cues of CB in fat metabolism remain elusive. This study demonstrates the CB inhibition of fat deposition by increasing the relative number of adipose tissue‐resident Treg cells (aTregs). Methods and Results: CB is administered orally to wild type (WT) mice fed with chow diet, which decrease fat deposition and adipogenic gene expression, associating with elevated serum levels of butyrate. Sodium butyrate (SB) feeding mimics the CB suppression of fat accumulation. Of note, the frequency of aTregs in both the CB and SB treatments, analyzed by flow cytometry, is markedly increased, accompanied by activated Wnt10b expression in white adipose tissues. However, CB and SB fail to inhibit fat deposition in Wnt10b ‐KO mice. Intriguingly, CB and SB are able to alleviate the obesity, fatty liver, and glucose abnormalities in high fat diet (HFD)‐fed WT mice. Conclusions: These findings suggest that CB, through its metabolite butyrate, inhibits fat deposition via potentiating aTreg cell generation, and support the option of CB and SB for therapeutic interventions in obesity and related disorders. Abstract : Clostridium Butyricum (CB) administration inhibits fat deposition by increasing the frequency of adipose tissue‐resident regulatory T cells, and CB improves the high‐fat diet‐induced obesity and associated disorders.