Efficient Synthesis of Symmetrical and Unsymmetrical Disulfides Using a Continuous Flow Method. Issue 6 (24th May 2022)

• Record Type: Journal Article
• Authors: Lo, Yung‐Han; Wang, Li‐Yu; Duraisamy, Tamilselvan; Govindan, Karthick; Kandasamy, Mohanraj; Lin, Wei‐Yu
• Is Part Of: Asian journal of organic chemistry. Volume 11:Issue 6(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-05-24
• Subjects: continuous flow -- disulfide -- microreactor -- unsymmetrical synthesis; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; 547.005
• DOI: 10.1002/ajoc.202200203
• Languages: English
• ISSNs: 2193-5807

Abstract

Abstract: This study described an efficient synthesis of disulfide from two thiols in a continuous flow reactor, using 1‐chlorobenzotriazole (BtCl) as an oxidant. It has been demonstrated that this method is feasible with a variety of aliphatic and aromatic thiols to produce a corresponding disulfide under mild conditions. Productivity of this process is determined by a high yield, a wide range of functional group compatibility, and the fact that disulfide is readily available in a short timeframe. This method enables the simple synthesis of a series of symmetrical and unsymmetrical disulfides. Abstract : A continuous flow system for the synthesis of various disulfides was demonstrated which was mediated by 1‐chlorobenzotriazole (BtCl) under mild conditions.