Efficient Synthesis of Symmetrical and Unsymmetrical Disulfides Using a Continuous Flow Method. Issue 6 (24th May 2022) - Lo, Yung‐Han
Abstract: This study described an efficient synthesis of disulfide from two thiols in a continuous flow reactor, using 1‐chlorobenzotriazole (BtCl) as an oxidant. It has been demonstrated that this method is feasible with a variety of aliphatic and aromatic thiols to produce a corresponding disulfide under mild conditions. Productivity of this process is determined by a high yield, a wide range of functional group compatibility, and the fact that disulfide is readily available in a short timeframe. This method enables the simple synthesis of a series of symmetrical and unsymmetrical disulfides. Abstract : A continuous flow system for the synthesis of various disulfides was demonstrated which was mediated by 1‐chlorobenzotriazole (BtCl) under mild conditions.