Characterization of chemical constituents with their antioxidant and anti-melanogenesis activities from the roots of Ampelopsis japonica. Issue 12 (15th June 2022)

• Record Type: Journal Article
• Authors: Lee, Chia-Lin; Jhan, Yun-Lian; Chiang, Hsiu-Mei; Chen, Yi-Hung; Chen, Chao-Jung; Chang, Yuan-Shiun
• Is Part Of: Natural product research. Volume 36:Issue 12(2022)
• Page Start: 3133
• Page End: 3137
• Publication Date: 2022-06-15
• Subjects: Ampelopsis japonica -- Vitaceae -- antioxidant -- anti-melanogenesis; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2021.1939335
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Three glycosylated stilbenes (1 –3 ), two anthraquinones (4, 5 ), one lignan (6 ), five tannins (7 –11 ), two amino acids (12, 13 ), and one auronol (14 ) were isolated from the root of Ampelopsis japonica . All compounds, except for 4, 6, and 11 were obtained from this species for the first time. Compounds 6 –9 could notably inhibit ROS generations in HaCaT keratinocyte cells with IC50 values of 5.28, 4.83, 0.87, and 1.66 μM, respectively. Compounds 8 –10 showed potent DPPH free radical scavenging effects with IC50 values of 14.37, 16.08, and 12.11 μM, individually. In anti-melanogenesis assay, only 8 and 9 could decrease 7.93% and 11.66% melanin contents induced by α-MSH in B16F10 melanoma cells at 40 μM and moderately inhibit tyrosinase activities. By far, galloylhamameloses 8 and 9 were found to exhibit both antioxidant and anti-melanogenesis properties that could be further developed as cosmeceutical agents for skin disorders. Graphical Abstract: UF0001