Acyl-homoserine lactones suppresses IEC-6 cell proliferation and increase permeability of isolated rat colon. Issue 3 (4th March 2014)

• Record Type: Journal Article
• Authors: Joe, Ga-Hyun; Andoh, Midori; Nomura, Mikako; Iwaya, Hitoshi; Lee, Jae-Sung; Shimizu, Hidehisa; Tsuji, Youhei; Maseda, Hideaki; Miyazaki, Hitoshi; Hara, Hiroshi; Ishizuka, Satoshi
• Is Part Of: Bioscience, biotechnology, and biochemistry. Volume 78:Issue 3(2014)
• Page Start: 462
• Page End: 465
• Publication Date: 2014-03-04
• Subjects: acyl-homoserine lactone -- IEC-6 cell -- cell proliferation -- intestinal permeability; Biotechnology -- Periodicals; Biochemistry -- Periodicals; 660.6
• DOI: 10.1080/09168451.2014.882748
• Languages: English
• ISSNs: 0916-8451

Abstract

Abstract: We investigated to determine whether a variety of acyl-homoserine lactones (AHLs) influences epithelial cell proliferation and mucosal permeability. 3-Oxo-C12 -homoserine lactone (HSL) and 3-oxo-C14 -HSL significantly suppressed IEC-6 cell proliferation. A significant increase in mucosal permeability was observed in isolated rat colon tissue exposed to C12 -HSL, 3-oxo-C12 -HSL, and 3-oxo-C14 -HSL. These data indicate that AHLs suppress epithelial proliferation and disrupt barrier function in intestinal mucosa.