Acyl-homoserine lactones suppresses IEC-6 cell proliferation and increase permeability of isolated rat colon. Issue 3 (4th March 2014) - Joe, Ga-Hyun
Abstract: We investigated to determine whether a variety of acyl-homoserine lactones (AHLs) influences epithelial cell proliferation and mucosal permeability. 3-Oxo-C12 -homoserine lactone (HSL) and 3-oxo-C14 -HSL significantly suppressed IEC-6 cell proliferation. A significant increase in mucosal permeability was observed in isolated rat colon tissue exposed to C12 -HSL, 3-oxo-C12 -HSL, and 3-oxo-C14 -HSL. These data indicate that AHLs suppress epithelial proliferation and disrupt barrier function in intestinal mucosa.