Antiallergic activity of rosmarinic acid esters is modulated by hydrophobicity, and bulkiness of alkyl side chain. Issue 7 (3rd July 2015)

• Record Type: Journal Article
• Authors: Zhu, Fengxian; Xu, Zhongming; Yonekura, Lina; Yang, Ronghua; Tamura, Hirotoshi
• Is Part Of: Bioscience, biotechnology, and biochemistry. Volume 79:Issue 7(2015)
• Page Start: 1178
• Page End: 1182
• Publication Date: 2015-07-03
• Subjects: rosmarinic acid -- esterification -- antiallergic activity -- hydrophobicity -- bulkiness; Biotechnology -- Periodicals; Biochemistry -- Periodicals; 660.6
• DOI: 10.1080/09168451.2015.1010478
• Languages: English
• ISSNs: 0916-8451

Abstract

Abstract: Methyl, propyl and hexyl esters of rosmarinic, caffeic and p -coumaric acids were tested for antiallergic activity, and rosmarinic acid propyl ester exhibited the greatest β -hexosaminidase release suppression (IC50, 23.7 μM). Quadratic correlations between pIC50 and cLog P ( r 2 = 0.94, 0.98, and 1.00, respectively) were observed in each acid ester series. The antiallergic activity is modulated by hydrophobicity, and alkyl chain bulkiness.