Antiallergic activity of rosmarinic acid esters is modulated by hydrophobicity, and bulkiness of alkyl side chain. Issue 7 (3rd July 2015) - Zhu, Fengxian
Abstract: Methyl, propyl and hexyl esters of rosmarinic, caffeic and p -coumaric acids were tested for antiallergic activity, and rosmarinic acid propyl ester exhibited the greatest β -hexosaminidase release suppression (IC50, 23.7 μM). Quadratic correlations between pIC50 and cLog P ( r 2 = 0.94, 0.98, and 1.00, respectively) were observed in each acid ester series. The antiallergic activity is modulated by hydrophobicity, and alkyl chain bulkiness.