1-Kestose consumption during pregnancy and lactation increases the levels of IgA in the milk of lactating mice. Issue 5 (4th May 2014)

• Record Type: Journal Article
• Authors: Jinno, Shinji; Nakamura, Yoshitaka; Nagata, Masashi; Takahashi, Takeshi
• Is Part Of: Bioscience, biotechnology, and biochemistry. Volume 78:Issue 5(2014)
• Page Start: 861
• Page End: 866
• Publication Date: 2014-05-04
• Subjects: 1-kestose -- Bifidobacterium spp. -- Fructooligosaccharides -- Bacteroides spp. -- IgA; Biotechnology -- Periodicals; Biochemistry -- Periodicals; 660.6
• DOI: 10.1080/09168451.2014.905179
• Languages: English
• ISSNs: 0916-8451

Abstract

Abstract: To examine the effect of dietary supplementation with 1-kestose on the IgA levels in milk, BALB/c mice were fed diets with or without 5% 1-kestose during pregnancy and lactation. The total and specific IgA levels in the milk were measured at 7 and 14 days after delivery. A two-way ANOVA with repeated measures resulted in a significant effect of 1-kestose-supplementation on total IgA concentrations ( p < 0.05) and the level of anti- Bacteroides IgA ( p < 0.05). A significant positive correlation was found between the mean count of Bacteroides spp. in maternal feces and the total IgA concentration in maternal milk ( r = 0.55, p < 0.05), suggesting a potential link between the gut and mammary gland immune system. In conclusion, this study demonstrated the effects of dietary prebiotics on milk IgA production. Graphical abstract: : Consumption of 1-kestose, a major component of fructooligosaccharides, by pregnant and lactating mice increased the total IgA concentration in the mouse milk.