Effect of herbal formulation intake on health indices in albino Wistar rat model. Issue 1 (10th November 2020)

• Record Type: Journal Article
• Authors: Naseem, Adila; Akhtar, Saeed; Manzoor, Muhammad Faisal; Sameen, Aysha; Layla, Anam; Afzal, Khurram; Karrar, Emad; Rahaman, Abdul; Ismail, Tariq; Ahmad, Nazir; Siddeeg, Azhari
• Is Part Of: Food science & nutrition. Volume 9:Issue 1(2021)
• Page Start: 441
• Page End: 448
• Publication Date: 2020-11-10
• Subjects: bilirubin -- hypercholesterolemia -- low‐density lipoprotein -- toxicity -- traditional medicine; Food industry and trade -- Periodicals; Food -- Periodicals; Nutrition -- Periodicals; 664
• DOI: 10.1002/fsn3.2009
• Languages: English
• ISSNs: 2048-7177

Abstract

Abstract: Dyslipidemia management activity of ginger‐, garlic‐, and lemon‐based herbal mixture was tested as paste and herbal extract in hypercholesterolemic adult male albino rats. Atherogenic diet‐induced hypercholesterolemia in rats was treated by supplementing the diet with 2.5% herbal paste (4.2 g/kg b.w.) or 2.5 ml oral gavage (20 ml/kg b.w.) of liquid herbal extract daily for 42 days. Hematological and serological outcomes of herbal formulation feeding were compared with the cholesterol‐fed positive control and normal control. The results suggest the significant ( p < .05) inhibitory properties of herbal paste and liquid extracts against dyslipidemia showing 31%–37%, 62%–68%, and 40%–56% lower levels of total cholesterol, triglycerides (TGs), and low‐density lipoprotein cholesterol (LDL‐C), respectively. Treating cholesterol‐fed animals with herbal paste and extract significantly ( p < .05) increased total protein (5–5.5 g/dl) and serum albumin (3.7–4.2 g/dl) concentration as compared to the normal control. Contrary to significant hypocholesterolemic activity, higher serum total bilirubin levels, that is, 0.70 mg/dl, were observed in rats subchronically exposed to herbal paste and liquid extracts. Nonsignificant ( p > .05) impact of herbal formula feeding was observed on hematological indices except lymphocyte counts, that is, 93% in rats fed on herbal paste. The results validate conventional hypocholesterolemic claims associated with ginger‐, garlic‐, and lemon‐based herbal formulations; however, deeper insight into their dose‐dependent response in hypercholesterolemia is necessitated to rule out the toxicological impact on the consumer. Abstract : Herbal medicines are primitive and conventional therapeutics for around 80% of the world's population due to their wide acceptability, availability, and affordability while their safety claims are in the process of validation in line with the consumer safety standards of the recent era. Findings of this subchronic exposure study on evaluating the synergistic effect of garlic‐, ginger‐, onion‐, apple cider vinegar‐, and honey‐based conventional herbal formulations against dyslipidemia validated existing therapeutic claims of the recipe.