Failure of multiplex meningitis/encephalitis (ME) NAT during cryptococcal meningitis in solid organ recipients. Issue 4 (11th June 2020)

• Record Type: Journal Article
• Authors: Pilmis, Benoit; Bougnoux, Marie‐Elizabeth; Guery, Romain; Senghor, Yaye; Le Monnier, Alban; Lanternier, Fanny; Bretagne, Stephane; Alanio, Alexandre; Lortholary, Olivier
• Is Part Of: Transplant infectious disease. Volume 22:Issue 4(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-06-11
• Subjects: Cryptococcus sp. -- meningitis/meningoencephalitis -- multiplex PCR; Transplantation of organs, tissues, etc -- Complications -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 617.01
• DOI: 10.1111/tid.13263
• Languages: English
• ISSNs: 1398-2273

Abstract

Abstract: Cryptococcal meningitis is a severe cause of central nervous system infections among immunocompromised solid organ transplant (SOT) patients. While new diagnostic methods as multiplex meningitis/encephalitis (ME) NAT (nucleic acid test) are increasingly used as a first‐line tool in hospital practice, data in HIV‐negative patients including SOT remain scarce. We report here false‐negative results of multiplex NAT among SOT patients with proven cryptococcal meningitis.