Advances in analysis, metabolism and mimicking of human milk lipids. (1st November 2022)

• Record Type: Journal Article
• Authors: Liu, Qian; Zhao, Junying; Liu, Yan; Qiao, Weicang; Jiang, Tiemin; Liu, Yan; Yu, Xiaowen; Chen, Lijun
• Is Part Of: Food chemistry. Volume 393(2022)
• Publication Date: 2022-11-01
• Subjects: AA arachidonic acid -- APCI atmosphere pressure chemical ionization -- BSSL bile salt–stimulated lipase -- Cer ceramides -- DAGs diacylglycerols -- DHA docosahexaenoic acid -- ELSD evaporative light scattering detector -- ESI electrospray ionization -- HILIC hydrophilic interaction liquid chromatography -- HMFSs human milk fat substitutes -- HPLC high performance liquid chromatography -- HRLC high resolution liquid chromatography -- IS internal standard -- IT ion trap -- LA linoleic acid -- LC-MS liquid chromatograph-mass spectrometry -- LC-SFAs long-chain saturated fatty acids -- LOP 1-linoleoyl-2-oleoyl-3-palmitoylglycerol -- MAGs monoacylglycerols -- MFGs milk fat globules -- MFGM milk fat globule membrane -- Mfsd2a major facilitator superfamily domain-containing protein 2a -- MS mass spectrometry -- MUFAs monounsaturated fatty acids -- NPLC normal phase liquid chromatography -- OOP 1, 2-dioleoyl-3-palmitoylglycerol -- OPL 1-oleoyl-2-palmitoyl-3-linoleoylglycerol -- OPO 1, 3-dioleoyl-2-palmitoylglycerol -- PA phosphatidic acid -- PC phosphatidylcholine -- PCA principal component analysis -- PE phosphatidylethanolamine -- PI phosphatidylinositol -- PG phosphatidylglycerol -- PLs polar lipids -- PL-CM chylomicron-PL -- PLRP2 pancreatic lipase-related protein 2 -- POP 1, 3-palmitoyl-2-dioleoylglycerol -- PTL pancreatic triglyceride lipase -- PUFAs polyunsaturated fatty acids -- QC quality control -- rac-POL 1(3)-palmitoyl-2-oleoyl-3(1)-linoleoylglycerol -- RF response factor -- RPLC reversed phase liquid chromatography -- SM sphingomyelin -- SPE solid phase extraction -- TAGs triacylglycerols -- TAG-CM chylomicron-TAG -- UPLC-Q-TOF-MS ultra-performance liquid chromatography-quadrupole-time-of-flight mass spectrometry -- UPC2 ultra-performance convergence chromatography; Human milk lipids -- Profiling lipids -- Digestion and absorption -- Biological activity -- Mimicking; Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; 664
• DOI: 10.1016/j.foodchem.2022.133332
• Languages: English
• ISSNs: 0308-8146

Abstract

Highlights: Qualitative and quantitative LC-MS detection and analysis technologies are reviewed. Concentrations, compositions and distributions of milk lipids differ between mammals. Forms, compositions and structures of lipids affect digestion, absorption and function. Molecular level and entire structure of lipids are important when mimicking human milk lipids. Abstract: Human milk lipids differ from the milk lipids of other mammals in composition and positional distribution of fatty acids. Analysis and detection technology of lipids is key to understanding milk lipids, and thus the concentrations, compositions and distribution characteristics of milk lipids are discussed. Differences between human milk lipids and their substitutes in form, composition and structure affect their digestion, absorption and function in infants. Characteristics and mimicking of human milk lipids have been intensively studied with the objective of narrowing the gap between human milk and infant formulae. Based on the existing achievements, further progress may be made by improving detection techniques, deepening knowledge of metabolic pathways and perfecting fat substitutes. This review detailed the characteristics of human milk lipids and related detection technologies with a view towards providing a clear direction for research on mimicking human milk lipids in formulae to further improve infant nutrition.