Facile fabrication of tyrosine-functionalized hypercrosslinked polymer for sensitive determination of nitroimidazole antibiotics in honey and chicken muscle. (30th September 2022)

• Record Type: Journal Article
• Authors: An, Yangjuan; Meng, Xufeng; Li, Shuofeng; Wang, Qianqian; Liu, Weihua; Hao, Lin; Yang, Xiumin; Wang, Chun; Wang, Zhi; Wu, Qiuhua
• Is Part Of: Food chemistry. Volume 389(2022)
• Publication Date: 2022-09-30
• Subjects: Hypercrosslinked polymer -- l-tyrosine -- Solid phase extraction -- Nitroimidazoles -- Determination; Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; 664
• DOI: 10.1016/j.foodchem.2022.133121
• Languages: English
• ISSNs: 0308-8146

Abstract

Highlights: Novel tyrosine-functionalized hypercrosslinked polymer (HCP@Tyr) were synthesized. HCP@Tyr showed high surface areas and good extraction performance to nitroimidazoles. HCP@Tyr was used to detect nitroimidazoles in honey and chicken tissue. Hydrogen bonding, π-stacking interactions played a vital role in the extraction. HCP@Tyr exhibited good application prospect for determination of other compounds. Abstract: The preparation of tyrosine-functional novel hypercrosslinked polymer (HCP@Tyr) was achieved by knitting 1, 3, 5-triphenylbenzene with l -tyrosine via simple Friedel-Crafts reaction. The HCP@Tyr displayed large surface area (1220 m 2 g −1 ) and high adsorption capacity (30 mg g −1 ) for nitroimidazoles (NDZs). With HCP@Tyr as potent sorbent, an efficient extraction method was developed to simultaneously extract five NDZs from honey and chicken muscle samples before high performance liquid chromatography-diode array detection. Under optimized conditions, the proposed method provided a good linearity in the range of 0.75–200.0 ng g −1 for honey and 1.5–100.0 ng g −1 for chicken muscle sample. Low detection limits (S/N = 3) were obtained to be 0.10–0.24 ng g −1 for honey and 0.15–0.30 ng g −1 for chicken muscle. The method recovery was 80.7–120% with relative standard deviations below 9.2%. The HCP@Tyr based method can serve as a reliable and sensitive tool for detection of NDZs in honey and chicken muscle samples.