Preparation of chiral aryl alcohols: a controllable enzymatic strategy via light-driven NAD(P)H regeneration. (14th March 2022)

• Record Type: Journal Article
• Authors: Xing, Xiu; Liu, Yan; Shi, Ming-Liang; Li, Kun; Fan, Xin-Yue; Wu, Zhong-Liu; Wang, Na; Yu, Xiao-Qi
• Is Part Of: New journal of chemistry. Volume 46:Number 13(2022)
• Page Start: 6274
• Page End: 6282
• Publication Date: 2022-03-14
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/d1nj06000g
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : Controllable and mild photoenzymatic production of chiral alcohols was realized by coupling a photochemical NAD(P)H regeneration system with ( R )- or ( S )-selective ketoreductases. Abstract : Controllable and mild photoenzymatic production of chiral alcohols was realized by coupling a versatile photochemical NAD(P)H regeneration system with ( R )- or ( S )-selective ketoreductases. The efficiency of NAD(P)H regeneration was improved using a Rhodium functionalized metal organic framework, namely Rh-UiO-67, to adjust and control electron transport and electron utilization. Furthermore, six different ketoreductases could be successfully immobilized on Rh-UiO-67 and combined with the light-driven NAD(P)H regeneration system to produce chiral aryl alcohols. Various chiral alcohols with complementary ( R )- and ( S )-conformations can be constructed by this method with high yields (97%) and excellent stereoselectivity (>99% ee).