Two new sesquiterpene dimers isolated from the roots of Saussurea lappa (Yunmuxiang). Issue 5 (4th May 2022)

• Record Type: Journal Article
• Authors: Lai, Sheng-Tian; Zhang, Ting; Wang, Hong-Qing; Xie, Jun; Liu, Jian-Bo; Chen, Ruo-Yun; Kang, Jie
• Is Part Of: Journal of Asian natural products research. Volume 24:Issue 5(2022)
• Page Start: 490
• Page End: 495
• Publication Date: 2022-05-04
• Subjects: Saussurea lappa (Yunmuxiang) -- sesquiterpene dimers -- anti-inflammatory bioactivity; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2021.2025049
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: Two new sesquiterpene dimers, lappadimers A and B, were isolated from the roots of Saussurea lappa (Yunmuxiang). Their structures were established on the basis of spectroscopic methods. They were found to have potential anti-inflammatory activity at 10 µ M and could reduce LPS-induced NO levels in murine macrophage, with inhibitory rates of 67% and 47%, respectively. Graphical Abstract: UF0001