Cobalt‐Mediated Decarboxylative/Desilylative C−H Activation/Annulation Reaction: An Efficient Approach to Natural Alkaloids and New Structural Analogues. Issue 16 (27th January 2022)

• Record Type: Journal Article
• Authors: Chen, Kang; Lv, Shan; Lai, Ruizhi; Yang, Zhongzhen; Hai, Li; Nie, Ruifang; Wu, Yong
• Is Part Of: European journal of organic chemistry. Volume 2022:Issue 16(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-01-27
• Subjects: Alkaloids -- C−H activation -- Cobalt -- Isoquinoline -- Synthesis; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.202101355
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract: A Co(II)‐mediated decarboxylative/desilylative C−H activation/annulation reaction for the efficient synthesis of 3‐arylisoquinolines has been developed. Using alkynyl carboxylic acid and alkynyl silane as terminal alkyne precursors, providing straightforward routes for the synthesis of natural alkaloids and novel structural analogues. Abstract : A Co(II)‐ mediated decarboxylative/desilylative C−H activation/annulation reaction for the synthesis of 3‐arylisoquinoline derivatives has been developed with a good functional group tolerance and wide applications.