Cobalt‐Mediated Decarboxylative/Desilylative C−H Activation/Annulation Reaction: An Efficient Approach to Natural Alkaloids and New Structural Analogues. Issue 16 (27th January 2022) - Chen, Kang
Abstract: A Co(II)‐mediated decarboxylative/desilylative C−H activation/annulation reaction for the efficient synthesis of 3‐arylisoquinolines has been developed. Using alkynyl carboxylic acid and alkynyl silane as terminal alkyne precursors, providing straightforward routes for the synthesis of natural alkaloids and novel structural analogues. Abstract : A Co(II)‐ mediated decarboxylative/desilylative C−H activation/annulation reaction for the synthesis of 3‐arylisoquinoline derivatives has been developed with a good functional group tolerance and wide applications.