The nanomicelles consisting of lotus root amylopectin and quinoa protein: Construction and encapsulation for quercetin. (1st September 2022)

• Record Type: Journal Article
• Authors: Liu, Kang; Zhang, Hai-Lin; Pan, Li-Hua; Li, Qiang-Ming; Luo, Jian-Ping; Zha, Xue-Qiang
• Is Part Of: Food chemistry. Volume 387(2022)
• Publication Date: 2022-09-01
• Subjects: Quinoa protein -- Lotus root amylopectin -- Self-assembly -- Encapsulation -- Quercetin; Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; 664
• DOI: 10.1016/j.foodchem.2022.132924
• Languages: English
• ISSNs: 0308-8146

Abstract

Highlights: LRA-coated Que-QP nanomicelles were constructed via self-assembly. Hydrophobic interaction and hydrogen bonding were the main driving forces. Que-QP-LRA nanomicelles exhibited a core-shell structure. The addition of LRA changed the secondary structure of QP. The composite nanomicelles enhanced stability and sustained release property of Que. Abstract: To improve the water solubility, stability and bioavailability of quercetin, the quercetin (Que)-quinoa protein (QP)-lotus root amylopectin (LRA) nanomicelles (Que-QP-LRA) were constructed via self-assembly in the present study. Results showed that a uniform and stable Que-QP-LRA nanomicelles was formed when the mass ratio of Que/QP/LRA was 2.5:6:24. Under this condition, the particle size, polydispersity index and zeta potential of the nanomicelles were 157.3 nm, 0.289 and −16.7 mV, respectively. Transmission electron microscopy exhibited that the Que-QP-LRA nanomicelles have a core-shell structure. The analysis of molecular interaction indicated that hydrogen bonding and hydrophobic interaction were the main driving forces to maintain stable structure of Que-QP-LRA nanomicelles. Additionally, the in vitro simulated digestion experiments suggested that Que-QP-LRA nanomicelles can enhance the stability of quercetin in the stomach and enable it to be sustained release in the intestine. These results suggested that Que-QP-LRA nanomicelles were beneficial for improving the bioavailability of quercetin.