Phenolic-protein interactions in foods and post ingestion: Switches empowering health outcomes. (December 2021)

• Record Type: Journal Article
• Authors: Guan, Hui; Zhang, Wenyuan; Sun-Waterhouse, Dongxiao; Jiang, Yang; Li, Feng; Waterhouse, Geoffrey I.N.; Li, Dapeng
• Is Part Of: Trends in food science & technology. Volume 118:Part A(2021)
• Page Start: 71
• Page End: 86
• Publication Date: 2021-12
• Subjects: Phenolics -- Protein -- Interaction -- Synergistic effects -- Multiple targets -- Health; Food industry and trade -- Periodicals; Food -- Biotechnology -- Periodicals; 664.005
• DOI: 10.1016/j.tifs.2021.08.033
• Languages: English
• ISSNs: 0924-2244

Abstract

Abstract: Background: Phenolic compounds are secondary metabolites with wide biological activities, and their biological activity is inseparable from their interactions with proteins. Phenolic-protein interactions will occur at the moment they are mixed, and this interaction will continue during food processing, handling, ingestion, digestion, metabolism and bioutilization, leading to a profound impact on the structure and properties of phenols and proteins. Scope and approach: This review summarizes current knowledge of the contributions of phenolic-protein interactions to the bioactivities and functional mechanism of phenolic-containing foods. We firstly provide a comprehensive review of the interactions between phenolic ingredients and dietary proteins, and the multi-step interactions between ingested phenolics or derived phenolic products and functional proteins (like enzymes, transporters, receptors and transcription factors (TFs)) inside the human body, along with the involved intermolecular forces. In addition, we have proposed the use of molecular docking for predicting such interactions, and demonstrated some docking results of dietary phenolics (or their derived metabolites) with human TFs. Key finding and conclusions: The phenolic-protein interactions in foods and post ingestion may function as multi-switches empowering health outcomes. This review asserts the need for increasing the knowledge of the interactions between the ingested phenolics or their derived products and all the protein biomolecules inside the human body. Highlights: Phenolics and proteins may interact before and after ingestion. Interactions of phenolic with enzyme, transporter, receptor and transcription factor. Interactions of phenolics with functional proteins in vivo promote human health. Phenolics multi-target interaction with proteins resulted in synergistic health effect.