Secondary metabolites with diversified structures from an endophytic fungus Colletotrichum gloeosporioides associated with a toxic medicinal plant Tylophora ovata. Issue 5 (4th May 2022)

• Record Type: Journal Article
• Authors: Sun, Sen-Feng; Cao, Hai-Yan; Yi, Cheng; Zhu, Shao; Qin, Zhi-Min; Liu, Yun-Bao
• Is Part Of: Journal of Asian natural products research. Volume 24:Issue 5(2022)
• Page Start: 468
• Page End: 482
• Publication Date: 2022-05-04
• Subjects: Endophytic fungus -- Colletotrichum gloeosporioides -- nor-triterpenoids -- α-pyrones -- anti-inflammation; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2021.1993832
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: Six new secondary metabolites, including two new nor-triterpenes (1 and 2 ), one new sesquiterpene (4 ), two new α -pyrone derivatives (6 and 7 ), and one new natural product (5 ) along with two known compounds (3 and 8 ) were isolated from an endophytic fungus Colletotrichum gloeosporioides obtained from a toxic medicinal plant Tylophora ovata . Their structures were elucidated by spectroscopic data analyses, while their absolute configurations were determined by CD and X-ray diffraction analyses. The in vitro anti-inflammatory activities of these compounds were evaluated. Graphical Abstract: UF0001