Strategies to enhance the production efficiency of Monascus pigments and control citrinin contamination. (June 2022)

• Record Type: Journal Article
• Authors: Shi, Jia; Qin, Xueling; Zhao, Yurong; Sun, Xiaoxiao; Yu, Xiang; Feng, Yanli
• Is Part Of: Process biochemistry. Volume 117(2022)
• Page Start: 19
• Page End: 29
• Publication Date: 2022-06
• Subjects: Monascus spp. -- Monascus pigments -- Production efficiency -- Citrinin -- Detoxification; Biochemical engineering -- Periodicals; Biotechnology -- Periodicals; Biochemistry -- periodicals; Biotechnology -- periodicals; Chemical Engineering -- periodicals; Génie biochimique -- Périodiques; Biotechnologie -- Périodiques; Biochemical engineering; Biotechnology; Periodicals; 660.63
• DOI: 10.1016/j.procbio.2022.03.003
• Languages: English
• ISSNs: 1359-5113

Abstract

Abstract: Monascus pigments (MPs) are the fermentation products of Monascus spp. They are widely used in the food industry as dyes, but are also used in medicine, cosmetics, textiles, and chemical industries owing to their antibacterial, anti-inflammatory, and antioxidant activities. Despite their widespread use, production of MPs still faces challenges such as improving production efficiency and reducing citrinin (CIT) contamination, which is critical for the healthy development of MPs industry. After a brief introduction to the applications of MPs, toxicity, and limitations of CIT, this review will examine strategies to improve MPs production efficiency and control CIT contamination of MPs. Particular attention is paid to new approaches such as using atmospheric and room temperature plasma mutagenesis (ARTP), microtiter plates (MTPs), and digital image analysis method (DCM) to achieve high-throughput screening of strains and obtain strains with low production of CIT and high yield of Monascus pigments, as well as regulating MPs production by modulating hyphae morphology of Monascus spp. Graphical Abstract: ga1 Highlights: Methods used to enhance the yield of Monascus pigments. Substrates for environment-friendly and low-cost production of Monascus pigments. Strategies for eliminating citrinin from Monascus pigments.