Health benefits of bioactive peptides produced from muscle proteins: Antioxidant, anti-cancer, and anti-diabetic activities. (May 2022)

• Record Type: Journal Article
• Authors: Islam, Md. Serajul; Wang, Hongxin; Admassu, Habtamu; Sulieman, Abdellatief A.; Wei, Fu An
• Is Part Of: Process biochemistry. Volume 116(2022)
• Page Start: 116
• Page End: 125
• Publication Date: 2022-05
• Subjects: Muscle proteins -- Enzymatic hydrolysis -- Bioactivity -- Anti-cancer activity -- Antioxidant activity -- α-Amylase and glucosidase inhibitory activity; Biochemical engineering -- Periodicals; Biotechnology -- Periodicals; Biochemistry -- periodicals; Biotechnology -- periodicals; Chemical Engineering -- periodicals; Génie biochimique -- Périodiques; Biotechnologie -- Périodiques; Biochemical engineering; Biotechnology; Periodicals; 660.63
• DOI: 10.1016/j.procbio.2022.03.007
• Languages: English
• ISSNs: 1359-5113

Abstract

Abstract: In recent years, there is a growing interest in the role of bioactive peptides obtained from natural food resources such as animal muscle proteins. Bioactive peptides/enzymatic protein hydrolysates are biomolecules broken down from proteins due to enzymatic hydrolysis, which usually contain 2–20 amino acids units with significant biological properties including antioxidant, anti-diabetic, and anti-cancer activities. Protein hydrolysates or peptides provide a natural therapeutics for controlling diabetes (type-II) by reducing amylase enzymatic activity and degrade the natural incretin hormone involved in blood glucose regulation. Such biological properties of peptides are highly correlated to sequence of amino acids and size. These bioactive molecules can be isolated, purified, and identified following different approaches such as gel filtration chromatography, Mass spectrometry approaches among others. In general, the animal muscles could be used as sustainable protein sources in the production of bioactive peptide-based functional foods and natural drugs for preventing chronic diseases. This review article aims to summarize the antioxidant, anti-diabetic, and anti-cancer activities of muscle proteins hydrolysates and purified bioactive peptides. Graphical Abstract: ga1 Highlights: This review paper discusses on functionality and bioactive characteristics of peptides. Bioactive peptides can be produced through several enzymatic hydrolysis. Specific bioactive peptides can be purified through different novel approaches. Polar and non-polar peptides has anti-cancer and anti-diabetic properties.