Metal-free synthesis of β-aminoketones by the reductive hydroamination of ynones. Issue 21 (23rd February 2022)

• Record Type: Journal Article
• Authors: Fu, Rui; Liu, Yu; Wu, Tao; Zhang, Xinyu; Zhu, Yang; Luo, Jiangbin; Zhang, Zhengyu; Jiang, Yaojia
• Is Part Of: Chemical communications. Volume 58:Issue 21(2022)
• Page Start: 3525
• Page End: 3528
• Publication Date: 2022-02-23
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d2cc00169a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : This paper describes a cascade method for the synthesis of β-aminoketones through the reductive hydroamination of alkynes under metal-free conditions. This process can be applied to synthesis of drug molecules including Proroxan and Propipocaine . Abstract : This study describes a cascade method for the synthesis of β-aminoketones through the reductive hydroamination of alkynes under very mild metal-free conditions. It allows for the rapid conversion of ynones and amines into corresponding β-aminoketones with a broad substrate scope and diverse functionalities. This straightforward and easy-to-handle reaction process can be successfully applied for the synthesis of Proroxan and Propipocaine, offering a potential option for the synthesis of drug molecules with the β-aminoketone skeleton.