Metal-free synthesis of β-aminoketones by the reductive hydroamination of ynones. Issue 21 (23rd February 2022) - Fu, Rui
Abstract : This paper describes a cascade method for the synthesis of β-aminoketones through the reductive hydroamination of alkynes under metal-free conditions. This process can be applied to synthesis of drug molecules including Proroxan and Propipocaine . Abstract : This study describes a cascade method for the synthesis of β-aminoketones through the reductive hydroamination of alkynes under very mild metal-free conditions. It allows for the rapid conversion of ynones and amines into corresponding β-aminoketones with a broad substrate scope and diverse functionalities. This straightforward and easy-to-handle reaction process can be successfully applied for the synthesis of Proroxan and Propipocaine, offering a potential option for the synthesis of drug molecules with the β-aminoketone skeleton.