Cancer stem cells: An overview of the pathophysiological and prognostic roles in colorectal cancer. (April 2022)

• Record Type: Journal Article
• Authors: Pashirzad, Mehran; Sathyapalan, Thozhukat; Sheikh, Afsana; Kesharwani, Prashant; Sahebkar, Amirhossein
• Is Part Of: Process biochemistry. Volume 115(2022)
• Page Start: 19
• Page End: 29
• Publication Date: 2022-04
• Subjects: Colorectal cancer -- Cancer stem cells -- Signal transduction -- Therapeutic approaches -- Chemoresistance; Biochemical engineering -- Periodicals; Biotechnology -- Periodicals; Biochemistry -- periodicals; Biotechnology -- periodicals; Chemical Engineering -- periodicals; Génie biochimique -- Périodiques; Biotechnologie -- Périodiques; Biochemical engineering; Biotechnology; Periodicals; 660.63
• DOI: 10.1016/j.procbio.2022.02.006
• Languages: English
• ISSNs: 1359-5113

Abstract

Abstract: Colorectal cancer (CRC) is one of the most common types of cancer globally. A subpopulation of tumour cells, cancer stem cells (CSC), is speculated to be responsible for tumor initiation, development, maintenance, metastasis, and recurrence. Colorectal cancer stem cells (CRC-SCs) have demonstrated some unique features, including a high level of heterogeneity and plasticity. This review summarizes the current understanding of CRC-SCs in the progression of CRC and the prognostic importance of these CSCs and their markers in colorectal cancer. Moreover, we have also discussed about various therapeutic approaches against markers-expressing CRC-SC. Highlights: Colorectal cancer (CRC) is one of the most common types of cancer globally. Cancer stem cells (CSC) is responsible for tumor metastasis and recurrence. Colorectal cancer stem cells (CRC-SCs) have high level of heterogeneity and plasticity. We summarizes the current understanding of CRC-SCs in the progression of CRC.