Fucoxanthin-loaded nanoparticles composed of gliadin and chondroitin sulfate: Synthesis, characterization and stability. (15th June 2022)

• Record Type: Journal Article
• Authors: Wang, Luhui; Wei, Zihao; Xue, Changhu; Tang, Qingjuan; Zhang, Tiantian; Chang, Yaoguang; Wang, Yuming
• Is Part Of: Food chemistry. Volume 379(2022)
• Publication Date: 2022-06-15
• Subjects: Gliadin nanoparticles -- Chondroitin sulfate -- Fucoxanthin -- Delivery system -- Physical stability -- pH-dependent; Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; 664
• DOI: 10.1016/j.foodchem.2022.132163
• Languages: English
• ISSNs: 0308-8146

Abstract

Graphical abstract: Highlights: Chondroitin sulfate (ChS) coated fucoxanthin- gliadin nanoparticles (FUC-Gli NPs). The driving forces of the Gli-ChS NPs formation were related to pH. Gli-ChS NPs generally increased the stability of FUC against UV irradiation. Adding ChS to FUC-Gli NPs enhanced their stabilities to ionic strength and heat. The system has the potential for sustained and targeted release of FUC in the body. Abstract: In this study, the fucoxanthin (FUC)-loaded gliadin nanoparticles (Gli NPs) stabilized by chondroitin sulfate (ChS) were fabricated. Results showed that the particle size and turbidity of Gli-ChS NPs were highly pH-dependent. Hydrogen bond, electrostatic interaction and hydrophobic interaction were involved in the formation of Gli-ChS NPs. The surface hydrophobicity of Gli NPs decreased remarkably after coating with ChS. FUC-Gli-ChS NPs increased the stability of FUC against heating and ultraviolet (UV) irradiation. Adding ChS to FUC-Gli NPs enhanced their stabilities to ionic strength and thermal treatment, especially in an acidic environment. Furthermore, FUC-loaded Gli-ChS NPs inhibited the FUC release in simulated gastric fluid (SGF), while enhanced the release of FUC in simulated intestinal fluid (SIF) and simulated colonic fluid (SCF). In summary, this work has important practical significance for the development of Gli NPs as nano-delivery systems for FUC or other hydrophobic compounds.