Evaluation and development of a novel pre-treatment method for mulberry leaves to enhance their bioactivity via enzymatic degradation of GAL-DNJ to DNJ. Issue 24 (10th November 2021)

• Record Type: Journal Article
• Authors: Takasu, Soo; Parida, Isabella Supardi; Kojima, Yoshihiro; Kimura, Toshiyuki; Nakagawa, Kiyotaka
• Is Part Of: Food & function. Volume 12:Issue 24(2021)
• Page Start: 12250
• Page End: 12255
• Publication Date: 2021-11-10
• Subjects: Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; Nutrition -- Periodicals; 664.07
• DOI: 10.1039/d1fo02307a
• Languages: English
• ISSNs: 2042-6496

Abstract

Abstract : We demonstrated the conversion of GAL-DNJ into DNJ improves mulberry leaves bioavailability and constructed a novel enzymatic-based method to induce the hydrolysis of GAL-DNJ to DNJ. Abstract : Mulberry leaves are rich in 1-deoxynojirimycin (DNJ) and 2- O -α-d -galactopyranosyl-deoxynojirimycin (GAL-DNJ). Compared to DNJ, the bioactive potency of GAL-DNJ is low. We proposed that the conversion of GAL-DNJ into DNJ may improve its bioavailability. We evaluated this hypothesis and constructed a novel enzymatic-based method to induce the hydrolysis of GAL-DNJ to DNJ in order to improve the therapeutic potency of mulberry leaves.