Novel approach towards 3, 7-disubstituted 1, 6-naphthyridin-4(1H)-ones exploiting cross-coupling and SNAr reactions of a dihalogenated compound. Issue 39 (26th September 2018)

• Record Type: Journal Article
• Authors: Dembélé, Ousmane; Montoir, David; Yvorra, Thomas; Sérillon, Dylan; Tonnerre, Alain; Duflos, Muriel; Robert, Jean-Michel; Bazin, Marc-Antoine
• Is Part Of: Tetrahedron letters. Volume 59:Issue 39(2018)
• Page Start: 3519
• Page End: 3523
• Publication Date: 2018-09-26
• Subjects: 1, 6-Naphthyridin-4(1H)-ones -- Suzuki-Miyaura reaction -- Buchwald-Hartwig amination -- Nucleophilic aromatic substitution -- Halodecarboxylation; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2018.08.013
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: A new access to 3, 7-disubstituted 1, 6-naphthyridin-4(1 H )-ones. Differential functionalization of 1, 6-naphthyridin-4(1 H )-ones. Palladium-catalyzed cross-coupling reactions and SN Ar reactions. Abstract: A new route towards the synthesis of a series of 3, 7-disubstituted 1, 6-naphthyridin-4(1 H )-ones in moderate to good yields is reported. The strategy involves the preparation of a 3, 7-dihalogenated compound that undergoes differential functionalization using palladium-catalyzed cross-coupling and SN Ar reactions.