Novel approach towards 3, 7-disubstituted 1, 6-naphthyridin-4(1H)-ones exploiting cross-coupling and SNAr reactions of a dihalogenated compound. Issue 39 (26th September 2018) - Dembélé, Ousmane
Graphical abstract: Highlights: A new access to 3, 7-disubstituted 1, 6-naphthyridin-4(1 H )-ones. Differential functionalization of 1, 6-naphthyridin-4(1 H )-ones. Palladium-catalyzed cross-coupling reactions and SN Ar reactions. Abstract: A new route towards the synthesis of a series of 3, 7-disubstituted 1, 6-naphthyridin-4(1 H )-ones in moderate to good yields is reported. The strategy involves the preparation of a 3, 7-dihalogenated compound that undergoes differential functionalization using palladium-catalyzed cross-coupling and SN Ar reactions.