Chemical Composition, Biological Activity, and Health-Promoting Effects of Withania somnifera for Pharma-Food Industry Applications. (29th December 2021)

• Record Type: Journal Article
• Authors: Sharifi-Rad, Javad; Quispe, Cristina; Ayatollahi, Seyed Abdulmajid; Kobarfard, Farzad; Staniak, Mariola; Stępień, Anna; Czopek, Katarzyna; Sen, Surjit; Acharya, Krishnendu; Matthews, Karl R.; Sener, Bilge; Devkota, Hari Prasad; Kırkın, Celale; Özçelik, Beraat; Victoriano, Montserrat; Martorell, Miquel; Rasul Suleria, Hafiz Ansar; Alshehri, Mohammed M.; Chandran, Deepak; Kumar, Manoj; Cruz-Martins, Natália; Cho, William C.
• Other Names: El-Sohaimy Sobhy Academic Editor.
• Is Part Of: Journal of food quality. Volume 2021(2021)
• Publication Date: 2021-12-29
• Subjects: Food industry and trade -- Quality control -- Periodicals; Food industry and trade -- Standards -- Periodicals; Food -- Periodicals; 664.07
• DOI: 10.1155/2021/8985179
• Languages: English
• ISSNs: 0146-9428

Abstract

Abstract : The Withania genus comes from the Solanaceae family and includes around 23 species, spread over some areas of the Mediterranean, Asia, and East Africa. Widely used in traditional medicine for thousands of years, these plants are rich in secondary metabolites, with special emphasis on steroidal lactones, named withanolides which are used as ingredients in numerous formulations for a plethora of diseases, such as asthma, diabetes, arthritis, impotence, amnesia, hypertension, anxiety, stress, cancer, neurodegenerative, and cardiovascular diseases, and many others. Among them, Withania somnifera (L.) Dunal is the most widely addressed species from a pharmacological and agroindustrial point of view. In this sense, this review provides an overview of the folk uses, phytochemical composition, and biological activity, such as antioxidant, antimicrobial, anti-inflammatory, and cytotoxic activity of W. somnifera, although more recently other species have also been increasingly investigated. In addition, their health-promoting effects, i.e., antistress, anxiolytic, adaptogenic, antirheumatoid arthritis, chemoprotective, and cardiorespiratory-enhancing abilities, along with safety and adverse effects are also discussed.