Cruciferous vegetable and isothiocyanate intake and multiple health outcomes. (1st May 2022)

• Record Type: Journal Article
• Authors: Li, Ni; Wu, Xiaoting; Zhuang, Wen; Wu, Chuncheng; Rao, Zhiyong; Du, Liang; Zhou, Yong
• Is Part Of: Food chemistry. Volume 375(2022)
• Publication Date: 2022-05-01
• Subjects: Cruciferous vegetables -- Isothiocyanates -- Health -- Umbrella review -- Meta-analysis -- Systematic review; ITCs isothiocyanates -- I3C indole-3-carbinol -- DIM diindolylmethane -- BITC benzyl isothiocyanate -- AITC allyl isothiocyanate -- SFN sulforaphane -- PEITC phenethyl isothiocyanate -- RCT randomized controlled trial -- OR odds ratio -- RR relative risk -- MD mean difference -- CI confidence interval -- AMSTAR a measurement tool to assess systematic reviews -- GRADE Grading of Recommendation Assessment, Development and Evaluation -- AhR aryl hydrocarbon receptor -- GSTM1 glutathione S-transferase M1 -- GSTT1 glutathione S-transferase T1; Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; 664
• DOI: 10.1016/j.foodchem.2021.131816
• Languages: English
• ISSNs: 0308-8146

Abstract

Highlights: Consumption of cruciferous vegetables was associated with a reduced risk of cancer. Per 100 g/d increment was associated with 10% decreased risk of all-cause mortality. Warfarin resistance caused by vitamin K-rich broccoli was reported. Caution was warranted for those allergies/hypersensitivities to the Brassica genus. Abstract: Isothiocyanates, bioactive phytochemicals of cruciferous vegetables, have chemopreventative efficacy. To clarify evidence of associations between cruciferous vegetable and isothiocyanate intake and various health outcomes, we conducted an umbrella review of meta-analyses and systematic reviews in humans. A total of 413 articles were identified, and 57 articles with 24 health outcomes were included. Consumption of cruciferous vegetables was associated with a reduced risk of all-cause mortality, cancers, and depression. Dose-response analyses revealed that a per 100 g/d increment was associated with a 10% decrease in the risk of all-cause mortality. Warfarin resistance caused by vitamin K-rich broccoli was reported. Caution was warranted for those allergies/hypersensitivities to the Brassica genus. The intake of cruciferous vegetables is generally safe and beneficial in humans. However the quality of the majority (68%) of evidence was low.