Allyl sulfones construction via copper catalysis from α-methylstyrene derivatives and sulfonyl chlorides. (5th January 2022)

• Record Type: Journal Article
• Authors: Liu, Lixia; Wang, Chengming
• Is Part Of: Tetrahedron letters. Volume 88(2022)
• Publication Date: 2022-01-05
• Subjects: Allyl sulfone -- Copper -- Radical -- Redox-neutral -- α-Methylstyrene; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2021.153553
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: A cheap copper-catalyzed ligand-free, regioselective alkene allylic sulfonylation reaction has been efficiently developed employing commercially available α-methylstyrene derivatives and sulfonyl chlorides. This redox-neutral protocol can be easily scale up to a gram scale. Abstract: Allyl sulfones are synthesized via Cu-catalyzed ligand-free regioselective sulfonylation reaction from easily obtained α-methylstyrene derivatives and sulfonyl chlorides. This redox-neutral protocol also features a low-cost metal catalyst, broad substrate scope, good functional group tolerance and could be smoothly amplified to a gram scale. The allylic sulfone products can be used in diverse radical coupling reactions.