Allyl sulfones construction via copper catalysis from α-methylstyrene derivatives and sulfonyl chlorides. (5th January 2022) - Liu, Lixia
Graphical abstract: A cheap copper-catalyzed ligand-free, regioselective alkene allylic sulfonylation reaction has been efficiently developed employing commercially available α-methylstyrene derivatives and sulfonyl chlorides. This redox-neutral protocol can be easily scale up to a gram scale. Abstract: Allyl sulfones are synthesized via Cu-catalyzed ligand-free regioselective sulfonylation reaction from easily obtained α-methylstyrene derivatives and sulfonyl chlorides. This redox-neutral protocol also features a low-cost metal catalyst, broad substrate scope, good functional group tolerance and could be smoothly amplified to a gram scale. The allylic sulfone products can be used in diverse radical coupling reactions.