Temperature‐Controlled Divergent Synthesis of Tetrasubstituted Alkenes and Pyrrolo[1, 2‐a]indole Derivatives via Iridium Catalysis. Issue 12 (30th September 2021)

• Record Type: Journal Article
• Authors: Liu, Siyu; Mao, Hui; Qiao, Jin; Zhang, Xiaoning; Lu, Yangbin; Gong, Xin; Jia, Aiqiong; Gu, Linghui; Wu, Xiaowei; Zhao, Fei
• Is Part Of: Asian journal of organic chemistry. Volume 10:Issue 12(2021)
• Page Start: 3308
• Page End: 3320
• Publication Date: 2021-09-30
• Subjects: Iridium -- C−H activation -- [3+2] annulation -- Tetrasubstituted alkene -- pyrrolo[1, 2-a]indole; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; 547.005
• DOI: 10.1002/ajoc.202100476
• Languages: English
• ISSNs: 2193-5807

Abstract

Abstract: We have achieved an Ir(III)‐catalyzed temperature‐controlled divergent synthesis of tetrasubstituted alkenes and pyrrolo[1, 2‐ a ]indole derivatives through C−H alkenylation/DG migration and [3+2] annulation, respectively. This method has various advantageous features: a) excellent regio‐ and stereoselectivity and good functional group tolerance, b) broad substrate scope and moderate to excellent yields, c) mild redox‐neutral reaction conditions and operational simplicity. Abstract : We report an Ir(III)‐catalyzed temperature‐controlled divergent synthesis of tetrasubstituted alkenes and pyrrolo[1, 2‐ a ]indole derivatives through C−H alkenylation/DG migration and [3+2] annulation, respectively. This protocol is characterized by excellent regio‐ and stereoselectivity, broad substrate scope, good functional group tolerance, moderate to excellent yields, mild redox‐neutral reaction conditions and operational simplicity.