Temperature‐Controlled Divergent Synthesis of Tetrasubstituted Alkenes and Pyrrolo[1, 2‐a]indole Derivatives via Iridium Catalysis. Issue 12 (30th September 2021) - Liu, Siyu
Abstract: We have achieved an Ir(III)‐catalyzed temperature‐controlled divergent synthesis of tetrasubstituted alkenes and pyrrolo[1, 2‐ a ]indole derivatives through C−H alkenylation/DG migration and [3+2] annulation, respectively. This method has various advantageous features: a) excellent regio‐ and stereoselectivity and good functional group tolerance, b) broad substrate scope and moderate to excellent yields, c) mild redox‐neutral reaction conditions and operational simplicity. Abstract : We report an Ir(III)‐catalyzed temperature‐controlled divergent synthesis of tetrasubstituted alkenes and pyrrolo[1, 2‐ a ]indole derivatives through C−H alkenylation/DG migration and [3+2] annulation, respectively. This protocol is characterized by excellent regio‐ and stereoselectivity, broad substrate scope, good functional group tolerance, moderate to excellent yields, mild redox‐neutral reaction conditions and operational simplicity.