Co-encapsulation of (–)-epigallocatechin-3-gallate and quercetin in double emulsion hydrogel beads: Microstructures, functional properties, and digestion behaviors. (30th March 2022)

• Record Type: Journal Article
• Authors: Hu, Miao; Liu, Guannan; Zhang, Wei; Du, Xiaoqian; Qi, Baokun; Li, Yang
• Is Part Of: Food chemistry. Volume 373:Part A(2022)
• Publication Date: 2022-03-30
• Subjects: Double emulsion -- Hydrogel beads -- Alginate -- Soybean protein isolate -- Microstructure -- Digestion; Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; 664
• DOI: 10.1016/j.foodchem.2021.131427
• Languages: English
• ISSNs: 0308-8146

Abstract

Graphical abstract: Highlights: EGCG and quercetin were successfully encapsulated in double emulsion hydrogel beads. EEs of EGCG and quercetin in hydrogel beads improved upon those of double emulsions. Sodium alginate and Ca 2+ formed a 3D network wherein the double emulsion adsorbed. Hydrogel beads inhibited oil digestion without decreasing quercetin bioavailability. Hydrogel beads increased the bioavailability of EGCG. Abstract: Co-loaded (–)-epigallocatechin-3-gallate (EGCG) and quercetin double emulsions and hydrogel beads were prepared, and their structure, functions, and digestion characteristics were investigated. The double emulsion particles were adsorbed by the cross-linked chains of the hydrogel beads. The encapsulation efficiencies of EGCG and quercetin within the hydrogel beads were higher than those within the double emulsion, while the antioxidant activities of the double emulsions were higher than those of the hydrogel beads. A lower amount of free fatty acids (FFAs) was released from the hydrogel beads than that released from the double emulsions. The bioavailability of EGCG was higher in the hydrogel beads than those in the double emulsions, while the quercetin bioavailability was not significantly different expect for the ratio of 3:7. The hydrogel beads remained intact in the stomach; however, numerous oil spills occurred in the small intestine. These data may improve double-emulsion-based delivery systems for controlled lipolysis and the release of co-encapsulated hydrophilic and lipophilic bioactive compounds.