Chitosan oligosaccharides-tripolyphosphate microcapsules as efficient vehicles for desalted duck egg white peptides-calcium: Fabrication, entrapment mechanism and in vivo calcium absorption studies. (15th January 2022)

• Record Type: Journal Article
• Authors: Zhao, Mengge; He, Hui; Guo, Danjun; Zhang, Xing; Jia, Lei; Hou, Tao; Ma, Aimin
• Is Part Of: Lebensmittel-Wissenschaft + Technologie =. Volume 154(2022)
• Publication Date: 2022-01-15
• Subjects: Desalted duck egg white peptides-calcium (DPs-Ca) -- Chitosan oligosaccharide (COS) -- Chitosan oligosaccharides-tripolyphosphate microcapsules -- Calcium delivery system -- Low calcium diet mouse model; Food industry and trade -- Periodicals; Food -- Composition -- Periodicals; Microbiology -- Periodicals; Nutrition -- Periodicals; 664.005
• DOI: 10.1016/j.lwt.2021.112869
• Languages: English
• ISSNs: 0023-6438

Abstract

Abstract: Microcapsules based on food-grade biopolymers are of particular interest for biological components delivery owing to their unique controlled release property. In present study, a novel calcium delivery system was obtained by gelation interaction of chitosan oligosaccharides (COS) with tripolyphosphate (TPP), and desalted duck egg white peptides-calcium (DPs-Ca) chelate was encapsulated to fabricate TPP-COS/DPs-Ca microcapsules. The solution containing 4% COS and 1.76% TPP, TPP pH of 9, and COS: DPs<1k -Ca ratio of 2:1, resulted in calcium content of microcapsules was 22 mg/g. The intermolecular forces, morphology characterizations, controlled calcium release and calcium absorption properties in vitro and vivo of microcapsules were investigated. The resulted showed that, material wall (COS) could prevent DPs-Ca avoiding stomach digestion and lead more calcium to enter the intestine, thus to promote calcium absorption. In low-calcium diet-induced calcium deficiency mice model, the analysis of serum indexes, bone indexes and micro-CT of bone trabeculae in mice revealed that TPP-COS/DPs-Ca could promote the absorption of calcium in enterocyte of the body, then to reduce the risk of osteoporosis and improve gut health. Overall, these results confirmed the potentialities of TPP-COS/DPs-Ca as nutraceuticals/functional food for oral calcium delivery to promote calcium absorption and improve gut health. Highlights: Ionic gelation interaction was used to prepare calcium delivery system. TPP-COS/DPs-Ca microcapsules restrained Ca 2+ release in stomach. Ca microcapsules promoted Ca uptake in low Ca diet induced Ca deficiency mice model. Calcium microcapsules could regulate gut microbiota and protect gut health.