Haloarene-guided cascade arylation of cyclic vinylogous esters under palladium catalysis. Issue 91 (1st November 2021)

• Record Type: Journal Article
• Authors: Lin, Yi-Ching; Yen, Ko-Wang; Lin, Hsuan-Jen; Yang, Yi-Chi; Wu, Yen-Ku
• Is Part Of: Chemical communications. Volume 57:Issue 91(2021)
• Page Start: 12119
• Page End: 12122
• Publication Date: 2021-11-01
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d1cc05006k
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A set of cascade unsymmetrical diarylation reactions were developed taking advantage of the differentiated reactivity of aryl bromides and chlorides under palladium catalysis. Abstract : A method is presented for the synthesis of diaryl cyclic vinylogous esters. The sequence of C(sp 3 )–H arylation events is programed under the differentiated reactivity of the aryl halides, and the optimized reaction system is effectively diverted from producing dihomo-arylated products. The site selectivity of the second arylation is notably modulated by the substitution pattern of the substrates.