Haloarene-guided cascade arylation of cyclic vinylogous esters under palladium catalysis. Issue 91 (1st November 2021) - Lin, Yi-Ching
Abstract : A set of cascade unsymmetrical diarylation reactions were developed taking advantage of the differentiated reactivity of aryl bromides and chlorides under palladium catalysis. Abstract : A method is presented for the synthesis of diaryl cyclic vinylogous esters. The sequence of C(sp 3 )–H arylation events is programed under the differentiated reactivity of the aryl halides, and the optimized reaction system is effectively diverted from producing dihomo-arylated products. The site selectivity of the second arylation is notably modulated by the substitution pattern of the substrates.