Synthesis of spirosuccinimides via annulative cyclization between N-aryl indazolols and maleimides under rhodium(iii) catalysis. Issue 83 (4th October 2021)

• Record Type: Journal Article
• Authors: Kang, Ju Young; An, Won; Kim, Suho; Kwon, Na Yeon; Jeong, Taejoo; Ghosh, Prithwish; Kim, Hyung Sik; Mishra, Neeraj Kumar; Kim, In Su
• Is Part Of: Chemical communications. Volume 57:Issue 83(2021)
• Page Start: 10947
• Page End: 10950
• Publication Date: 2021-10-04
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d1cc04599g
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : The rhodium(iii )-catalyzed spiroannulation reaction between N -aryl indazolols and maleimides is described herein. The developed method is showcased by the spirocyclization with bioactive molecule-linked and chemical probe-linked maleimides. Abstract : The rhodium(iii )-catalyzed spiroannulation reaction between N -aryl indazol-3-ols and maleimides is described herein. The developed method is showcased by the construction of spirosuccinimides using bioactive molecule-linked and chemical probe-linked maleimides. Combined mechanistic investigations including the determination of an isolable rhodacycle complex aided the elucidation of a plausible reaction mechanism.