Synthesis of spirosuccinimides via annulative cyclization between N-aryl indazolols and maleimides under rhodium(iii) catalysis. Issue 83 (4th October 2021) - Kang, Ju Young
Abstract : The rhodium(iii )-catalyzed spiroannulation reaction between N -aryl indazolols and maleimides is described herein. The developed method is showcased by the spirocyclization with bioactive molecule-linked and chemical probe-linked maleimides. Abstract : The rhodium(iii )-catalyzed spiroannulation reaction between N -aryl indazol-3-ols and maleimides is described herein. The developed method is showcased by the construction of spirosuccinimides using bioactive molecule-linked and chemical probe-linked maleimides. Combined mechanistic investigations including the determination of an isolable rhodacycle complex aided the elucidation of a plausible reaction mechanism.